Wissenschaftler der Stanford University haben herausgefunden, dass das Hinzufügen einer bestimmten Art von Meeresfrüchten zu Ihrer Ernährung die Zeichen des Alterns umkehren kann

Forscher haben herausgefunden, dass die Nahrungsergänzung mit dem Meeresorganismus Ascidiacea, auch bekannt als Meeresqualle, einige der wichtigsten Anzeichen des Alterns in einem Tiermodell umkehrt.

Eine neue Studie mit einem Tiermodell zeigt, dass die Ergänzung Ihrer Ernährung mit Meeresorganismen Ascidiacea, auch bekannt als Meeressprays, einige der wichtigsten Zeichen des Alterns umkehrt.

Während der Jungbrunnen, die legendäre Quelle, die jedem, der darin badet oder sein Wasser trinkt, die Jugend zurückgibt, eine offensichtliche Fantasie ist, arbeiten Wissenschaftler hart daran, Wege zu finden, um das Altern zu bekämpfen. Einige dieser Wissenschaftler haben überraschende Fortschritte gemacht: Sie entdeckten, dass die Ergänzung einer Meeresspritz-Diät jedoch einige der wichtigsten Zeichen des Alterns umkehrt. Obwohl noch mehr Forschung erforderlich ist, um die Wirkung beim Menschen zu verifizieren, sind die Ergebnisse sehr vielversprechend, da die Studie an Mäusen durchgeführt wurde.

Wenn Sie in den Spiegel schauen und Ergrauen und Falten sehen oder wenn Sie den Namen eines engen Freundes vergessen, möchten Sie vielleicht ein Medikament, das die Auswirkungen des Alterns stoppen oder sogar umkehren kann.

Laut einer neuen Studie ist dies möglicherweise keine dumme Idee. Forscher der Xi’an Jiaotong University Liverpool, der Stanford University, der Shanghai Jiao Tong University und der University of the Chinese Academy of Sciences haben entdeckt, dass die Nahrungsaufnahme des Meerestiers Ascidiacea, auch bekannt als Meeresqualle, einige wichtige Zeichen des Alterns in einem umkehrt Tiermodell.

Meeresbrunnen für Anti-Aging

Meeresbrunnen können roh gegessen werden und sind in Gerichten aus Korea (wo sie als Meongge oder 멍게 bekannt sind) und Japan (hoya oder ホ) zu finden. Kredit: japatocal

Seejets können roh gegessen werden und sind in Rezepten aus Korea (wo sie als Meongge oder 멍게 bekannt sind) und Japan (hoya oder ホ) zu finden. Diese Wasserlebewesen enthalten die für die Prozesse des menschlichen Körpers notwendige Substanz Plasmogene. Plasmalogene kommen natürlicherweise in unserem ganzen Körper vor, insbesondere in Herz-, Gehirn- und Immunzellen, aber die Menge in unserem Körper nimmt mit zunehmendem Alter ab. Dieser Verlust ist auch ein Merkmal verschiedener neurodegenerativer Erkrankungen, einschließlich[{” attribute=””>Alzheimer’s and Parkinson’s.

The researchers evaluated the effects of adding plasmalogens to the food of elderly mice to see whether increasing plasmalogen levels may prevent the effects of aging.  They discovered that the supplements had a significant impact on the mice’s learning abilities and physical symptoms.

Professor Lei Fu, the corresponding author of the study, says: “Our research suggests that plasmalogens may not just stop cognitive decline, but may reverse cognitive impairments in the aging brain. Additionally, aged mice fed with the plasmalogens grow new black hair that is thicker and glossier than aged mice not fed the supplement.”

This study is the first to show, in detail, how plasmalogens affect the aging brain.

Sea Squirts

The sea organisms Ascidiacea, also called sea squirts, contain substances called plasmalogens, which are vital to our body processes. Credit: Prilfish

Making new connections

The effects of the plasmalogen supplement on learning and memory were evaluated by training mice to navigate a Morris water maze, which consists of a pool of water with a platform that acts as a resting place. Mice typically dislike swimming, so after five days of training, they remember where the platform is and swim directly to it as soon as they enter the pool. Older mice, on the other hand, take longer to locate the platform following the same amount of training.

Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement.

To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain. They found that mice that were fed the plasmalogen supplement had a higher number and quality of synapses – the connections between neurons – than the aged mice not given the supplements.

Sea Squirts Improve Learning and Memory in Mice

Aged mice showed improved learning and memory when fed with plasmalogen supplements from Ascidiacea – also known as sea squirts. In this study, mice were trained to find a hidden platform in a pool of water (Morris water maze), and the image shows the paths they took to reach the platform. After five days of training, young mice were able to remember the platform’s location, whereas aged mice took longer and swam further to reach the platform as they forgot its location. However, when fed a plasmalogen supplement, the aged mice took a shorter, quicker route to the platform than those not given the supplement – suggesting improved cognitive function. Credit: Lei Fu

Synapses are a fundamental part of our neural networks and, therefore, crucial for learning and memory. Our synapses tend to be very plastic as children, but they decrease in number and deteriorate with age and in neurogenerative diseases, resulting in cognitive impairments.

Accordingly, in this study, the aged mice fed with plasmalogen supplements showed greater potential for learning new skills and creating new neural networks than the aged mice whose diet was not supplemented. This suggests that dietary plasmalogens can halt the age-related deterioration of synapses.

A further characteristic of getting older, and thought to be a significant factor in neurodegeneration, is inflammation in the brain. Too much inflammation can have a negative effect on cognitive ability, as the brain’s immune system becomes overactive and turns on itself, attacking neurons and preventing synapses from functioning correctly.

In this study, the inflammation in aged mice was greatly decreased in those given plasmalogen supplements compared to those on a normal diet, providing some insight as to why they performed better in learning and memory tasks.

Ascidiae Seescheiden

There are many varieties of sea squirts (Ascidiae). Some are shown in Ernst Haeckel’s Kunstformen der Natur (1904). Credit: Ernst Haeckel

Possible pathways of action

Although it is still unclear how dietary plasmalogen supplements seem to cause such significant changes in learning and memory, Professor Fu speculates on possible pathways of action.

“We found that plasmalogens significantly increase the number of molecules that aid the growth and development of neurons and synapses in the brain. This suggests that plasmalogens can promote neuroregeneration.

“There is also an increasing body of evidence that plasmalogens directly affect the structural properties of synapses. Plasmalogens may increase the fluidity and flexibility of synaptic membranes, affecting the transmission of impulses between neurons.”

Additionally, Professor Fu explains that plasmalogens may also have indirect effects on our brains.

“Some studies have shown that dietary plasmalogens affect the microorganisms in the gut. It has been widely reported that the connection between the organisms in our gut and our brain influences neurodegeneration. It may be the plasmalogen’s effect on this connection that causes the improvements in learning and memory are seen in this study.”

Professor Fu is so convinced by the results of this study that he takes a plasmalogen supplement each day.

“For the first time, we show that plasmalogen supplements might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.

“The oral intake of plasmalogens could be a feasible therapeutic strategy to improve cognitive function in older people.”

So, it could be that a pill to keep you young may not be such an unrealistic proposition after all – as long as it contains sea squirts.

Reference: “Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice” by Jinxin Gu, Lixue Chen, Ran Sun, Jie-Li Wang, Juntao Wang, Yingjun Lin, Shuwen Lei, Yang Zhang, Dan Lv, Faqin Jiang, Yuru Deng, James P. Collman and Lei Fu, 23 February 2022, Frontiers in Molecular Biosciences.
DOI: 10.3389/fmolb.2022.815320

Leave a Comment